Sunday, August 19, 2012

Winstrol Depot!


Winstrol is a popular brand name for the anabolic steroid stanozolol. This compound is a derivative of dihydrotestosterone, although its activity is much milder than this androgen in nature. It is technically classified as an anabolic steroid, shown to exhibit a slightly greater tendency for muscle growth than androgenic activity in early studies. While dihydrotestosterone really only provides androgenic side effects when administered, stanozolol instead provides quality muscle growth. The anabolic properties of this substance are still mild in comparison to many stronger compounds, but it is still a ggod, reliable builder of muscle. Its anabolic properties could even be comparable to Dianabol, but Winstrol does not have the same tendency for water retention. Stanozolol also contains the same c17 methylation we see with Dianabol, an alteration used so that oral administration is possible. To spite this design however, there are many injectable versions of this steroid produced. Since stanozolol is not capable of converting into estrogen, an anti-estrogen is not necessary when using this steroid, gynecomastia is not a concern even among the most sensitive individuals. Since estrogen is also the cause of water retention, instead of bulk look, Winstrol produces a lean, quality look with no fear of excess subcutaneous fluid retention. This makes it a great steroid to use during cutting cycles, when water and fat retention are a major concern. It is also very popular among athletes in combination strengthspeed sports such as Track and Field.

Primobolan!


Primobolan (also known as Primo) is the common name given to the drug Methenolone Enanthate. It is an injectable steroid that is rather mild in nature when compared to other anabolic steroids (AS), and is generally seen as a more steroid more anabolic in nature rather than an androgenic one. Primo also comes in an oral form called Methenolone Acetate, however due to the non-alkylation of the methenolone in this form, it is not realistically a very useful drug for the male bodybuilder as the liver will mostly destroy the methenolone acetate ingested.Primo is quite a unique steroid of which there are no other steroids quite like it. Firstly, Primo does not aromatise to estrogen, thus estrogen related side-effects are not seen in Primo use. This means that acne, water retention, gyno, etc, are all not concerns when using Primo. Thus primo becomes a very useful steroid for those who are easily prone to undesirable side effects such as acne and gyno. Due to the low water retention seen in its use, Primo is often used effectively when cutting. It is not only effective when cutting due to low/nil water retention, bit it also proves very useful when cutting due to its anabolic nature and nitrogen retention properties, which basically means that it holds onto muscle very well when in a calorie deficient mode as one would be when cutting.

Friday, July 13, 2012

What You Should Know About Glutamine


What You Should Know About Glutamine. While traditionally it's the major muscle building or fat loss supplements that get all the attention - such as creatine, protein powder, nitric oxide, caffeine, and fat burning stacks - glutamine is also a supplement that can offer you many advantages that you may want to consider. Here are some of the things you should know about glutamine. What Is Glutamine? Most people think of glutamine as the bodybuilding supplement, but glutamine really is one of the most abundant amino acids in the body. It isn't classified directly as an essential amino acid because the body can manufacture it up to some degree from other amino acids in the body. The glutamine that you currently have in your system is primarily stored in your muscles, with the remainder being found in the lungs, which is the site where glutamine is manufactured in the body.Potentially the most important use for glutamine in your body is with the immune system as it serves to prevent illness, speed recovery, and enhance the way the body feels and functions.In addition to this, glutamine also plays a role in DNA synthesis and as an alternative source of fuel for the brain. Finally, glutamine helps to prevent the catabolic reactions that occur in the body when cortisol is present, which is a benefit that is especially interesting to those who are involved with building muscle tissue. What Glutamine Should Be Used For Because of all the different functions of glutamine in the human body, it can be used for a wide variety of purposes by both normal individuals as well as those who are under the care of a medical professional. One instance where glutamine is administered quite heavily is when a wound is present, as it tends to speed up the healing process. Burn victims are often given very large doses of glutamine for this purpose. Glutamine is also useful for helping to prevent or treat inflammatory bowel disease. This is due to the fact that it helps to protect the lining of the gastrointestinal tract where problems often take place. Only individuals who have consulted with a medical professional should be using glutamine for this purpose however, so that is one important thing to note. Many people would be surprised to know that some studies performed on animals also demonstrate that glutamine can work as an appetite suppressant in those who are obese, so this could potentially make it a very beneficial supplement for those who are on a fat loss diet. Individuals who are suffering from cancer typically show very low levels of glutamine in their system, which makes it a good option for adding to their treatment program. It's especially used when the cancer patient is undergoing chemotherapy since it will help protect the lining of the small and large intestines, which are at a high risk during this process. Finally, and the primary reason you are most likely interested in glutamine supplementation is its' role in athletic performance. When you train very hard for days in a row your muscles glutamine stores will begin to become depleted. Additionally, since you want your body to be in as much of an anabolic process as possible and glutamine helps prevent the negative effects of cortisol in the body (which tend to break muscle tissue down), this alone makes it very useful for athletes or those involved heavily with their workout programs. In one study from the Applied Physiology, Nutrition, and Metabolism journal researchers tested the impact of glutamine and carbohydrate supplementation on endurance training and found that when the endurance exercise was performed past the one hour mark, supplementing with both the carbohydrate and glutamine mixture demonstrated a reduced blood ammonia level in the athletes, helping to ward of fatigue as they continued with their workout.So, regardless of whether you're a strength athlete or someone training for a long-distance endurance event, glutamine supplementation could prove to be very useful for you. Food Sources Of Glutamine Most people will be taking in glutamine from their daily diet - how much though is the question. The best sources of glutamine in the human diet include beef, pork, chicken, milk, yogurt, cottage cheese, raw spinach,parsley, and cabbage. Strict vegetarians are going to be at a higher risk of deficiency so it will be especially important for them to consider taking it in supplemental form as well. Even those who are eating a mixed diet may not be able to get in enough to meet their needs if they are exercising intensely, especially if they are on a reduced calorie, fat loss diet, so again adding a supplement is a wise move. How To Supplement With Glutamine When it comes to choosing your glutamine supplement, you have a variety of options. For easy ingestion, it comes in capsule, powder, and liquid form, so whatever your preference is you can easily find a supplement to match. You'll have to watch too because many protein powders will also have glutamine added in, so you may be able to combine these supplements if you choose wisely. Many times it won't be as much glutamine as what you'd get in a concentrated glutamine supplement, so assess your needs to determine which is the best option for you. How much glutamine you take each day will depend on your diet and purpose (exercise intensity, health status, additional lifestyle stress, etc), but a good recommendation is to start with a five gram serving two to three times a day and see how you feel. Ideally you would take one serving immediately after your workout as this is when your body is in its most damaged state and then also right before bed since that's the time when the healing and repair process really takes place. Conclusion So, next time you're putting together your supplement order, keep glutamine in mind. It's a relatively cost-effective supplement but could make noticeable results to your progress. Considering it can take months of hard work to build the muscle you have, you really do want to be doing everything you can to prevent losing that muscle mass.

Friday, June 29, 2012

Ipamorelin


Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry research program, Ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. The specificity of ipamorelin makes this PEPTIDE a very interesting candidate for future clinical development and research.

Thursday, June 28, 2012

Whey Protein Benefits!


Here's the skinny on whey protein benefits: Just as we know that not all carbs or fats are treated the same by your body, we also know that proteins are unique in their own right. Casein (the slow protein) and whey protein do a whole lot more than just enhance protein synthesis. In a new study, rats were administered whey protein or casein and put through a muscle overload protocol. Researchers strapped tiny weights on the rat subjects’ backs and electrocuted the floor, which made the rats jump up— similar to a person doing weighted jump squats. At the end of the study, it was found that whey protein reduced muscle damage but also enhanced liver antioxidant levels. Interestingly, levels of TBARS (ThioBarbituric Acid Reactive Substances)— a well-known biomarker of oxidative damage or free radical damage that cause cell destruction— are known to increase in plasma after weightlifting; however, TBARS were lowered after whey protein consumption. Additionally, whey protein increased total liver glutathione levels, which is a potent antioxidant. Another interesting finding was that the rats were administered the exact same amount of protein, yet the whey protein group had larger increases in muscle mass. These results suggest that the potent biochemical antioxidant actions of whey protein mediated a reduction in cellular damage to both liver and muscle, resulting in enhanced muscle and bodyweight. In terms of the anabolic responses, whey may have an advantage over casein in that it’s a potent antioxidant. It’s also been demonstrated that whey has the ability to inhibit angiotensin II, which is a potent vessel constrictor— so you may even get better muscle pumps with whey protein compared to other protein powders. Whey Protein Hydrolysates: Get Better Pumps!! Whey protein is not only a “fast-acting” protein as it has been known for years, but it has many more benefits for bodybuilding. It may help you get better pumps in the gym. The vascular endothelium is a single-cell layer in blood vessels that influences vascular health and risk of disease by regulating vasoconstriction and vasodilation, blood pressure, blood clotting, etc.2Bioactive peptides derived from food, especially milk proteins, exert a wide range of biological actions including decreased blood pressure and improved endothelial function. Milk is a rich source of angiotensin-converting enzyme (ACE) inhibitory peptides. ACE inhibition prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Many people with high blood pressure are prescribed ACE-inhibitor drugs to lower blood pressure, but bodybuilders may get a similar effect with whey protein hydrolysates. Most bodybuilders take a nitric oxide (NO) product before exercise to increase muscle pumps, but taking a new and novel whey protein shake may also help with getting better pumps. A researcher from the University of Connecticut investigated a new whey protein hydrolysate and its effects on vasodilation. The active whey supplement was a proprietary peptide isolated from a whey protein hydrolysate (NOP-47, Glanbia Nutritionals, Twin Falls, ID). Subjects consumed one serving a day of NOP-47 or a placebo for two weeks. At the end of the study, researchers found that acute ingestion of NOP-47 significantly increased blood vessel dilation at 30, 60 and 90 minutes, post-ingestion. This means the daily ingestion of a whey protein hydrolysate may be a great way to facilitate blood flow in the gym, as a single serving enhanced vasodilation 90 minutes after consumption. OK, but what about burning fat— which protein is #1 in that category? What About Thermogenesis? Which Protein Blend is Best? Scientists are finally starting to realize that increasing protein can accelerate weight loss. Protein not only increases energy expenditure, but also decreases energy intake through mechanisms that influence appetite control. Their addition to foods, meals, and diets decreases the glycemic index and, when exchanged for carbohydrates, the glycemic load as well— with potential benefits for glucose tolerance and insulin sensitivity. The energy cost of digesting, absorbing, and metabolizing protein (23 percent) is greater than that of either carbohydrate (6 percent) or fat (3 percent).Researchers from Switzerland investigated the thermogenic effects of three proteins: whey protein, casein, and soy. Subjects were men and women who consumed a shake consisting of 50 percent protein, 40 percent carbohydrates, and 10 percent fats. So which protein came out on top for being the most thermogenic? You guessed it: WHEY PROTEIN WAS MORE THERMOGENIC THAN ANY OTHERPROTEIN. The consumption of whey protein also resulted in enhanced fat oxidation, compared to soy protein. The scientists had a few ideas as to why whey was more thermogenic than other proteins. 1) Whey proteins are more rapidly digested and absorbed than casein, and this improves protein synthesis. Increased protein synthesis has been proposed as one possible mechanism responsible for the increased thermogenesis observed after high-whey protein consumption. After consumption of whey protein, the rate of protein synthesis is faster— twofold greater (68 percent, compared to 31 percent with casein). Ever notice when you eat a big steak, you start sweating? The energy cost of digesting, absorbing, and metabolizing protein (23 percent) is greater than that of either carbohydrate (6 percent) or fat (3 percent).This means the greater increases in protein synthesis resulted in a net greater energetic cost, which increased thermogenesis. It takes energy to increase protein synthesis! Consequently, differences in the rate of protein synthesis after whey, casein, and soy ingestion may explain the small, but significant, differences in thermic effect observed after whey protein. 2) Researchers speculated that increased glucagon secretion might enhance fat oxidation. Whey protein, contrary to what one would expect, promotes fat loss by enhancing the release of glucagon (builds muscle, burns fat). Glucagon stimulates the breakdown of glycogen stored in the liver. When blood glucose levels are high, the liver takes up large amounts of glucose. Under the influence of insulin, much of this glucose is stored in the form of glycogen. Glucagon activates hepatic gluconeogenesis. Gluconeogenesis is the pathway by which substrates such as amino acids are converted to glucose. As such, it provides another source of glucose for blood. Glucagon also appears to have a minor effect of enhancing lipolysis of triglycerides in adipose tissue, which could be viewed as an additional means of conserving blood glucose by providing fatty acid fuel to most cells. For example, Glucagon-like peptide-2 (GLP-2) is a nutrient-regulated intestinotrophic hormone derived from proglucagon in the distal intestine. GLP-2 has been found to be stimulated after whey protein consumption. Another study found that insulin and glucagon responses increased with increased protein load for whey protein and casein, but the effect was more pronounced for glucagon after whey consumption. A higher dose of protein or its hydrolysate will result in a lower insulin:glucagon ratio, an important parameter for the control of postprandial substrate metabolism. Another study found that insulin and glucagon responses to whey protein resulted in lower respiratory quotients, indicative of increased fat oxidation, after a breakfast meal containing whey protein— compared to meals containing casein or soy.Whereas it is tempting to suggest that the elevated glucagon concentrations observed after whey consumption may have interfered with insulin’s antilipolytic effects and permitted fat oxidation to continue at, more or less, fasting concentrations, evidence for the lipolytic effects of glucagon after whey protein consumption has been reported.This is just another reason to throw some whey protein powder in your shaker cup when coming home from the gym!

Wednesday, May 9, 2012

Follistatin!


Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh). Follistatin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids and having a total molecular mass of 31.5kDa. The FST is purified by proprietary chromatographic techniques.

Monday, May 7, 2012

IGF1


IGF-1 is naturally produced in the liver as a result of GH (Growth Hormone) metabolism in the presence of insulin. Muscle tissue can also produce IGF-1 by way of an intracellular response. In fact, one of the benefits of training sets that result in an intense burn, or stretch position training, is the production of natural IGF-1. It is also a side effect of oral 17-ALFA ALKYLATED STEROIDS, which cause a higher release of IGF-1 from the liver. IGF-1 receptors exist throughout muscles and organs such as the heart, spleen, small intestines, and kidneys with a higher concentration of receptors exerting effects upon organs. IGF-1 is extremely anabolic, far more so than GH or Insulin.

Sunday, May 6, 2012

What to look for in gym?

When looking for a gym or fitness center I believe you should ultimately go where to use couching knowledge and you feel the most comfortable or really what your gut instinct tells you. The following information is not meant to knock any fitness facility or gym. This info is for you, the reader, to help you spend your money the smartest and wisest ways possibly, especially in a tighter economy. None of us want to waste our hard-earned money at a fitness center where we are not getting a lot of product and service for our money. Where you choose to workout is your business and "to each his own". Whatever gets you moving and healthier is a great choice anyway. In the late 2006's after I received the coaching certificate the first job I had as a personal trainer was in Tehran, Iran. That job was with Bodybuilding and Fitness Center; at the time they only had 5 gyms (now they have nearly 40 gyms). The one I worked in was nearly 10,000 square meter and was always clean, with lots of equipment, free classes with membership, knowledgeable staff, and very reliable. I was the youngest personal trainer so I had to really work hard to market myself. One of the ways I did this was to take on another job with the same gym. The job I took was personal trainer, supplement and diet consultation. This meant taking the responsibilities of a trainer who helped all members with a few free sessions to get them integrated into the gym. This helped me increase my personal training business, but more importantly humbled me. I was humbled with the additional position because to do this job you also had to put back all of the weights that were left out on the floor or out of place each night, sometimes fill in at the front desk, call and confirm appointments, check on the status of new and existing members, and all kinds of other little jobs... all for about 4.00 Euros an hour. After my first job I was hired by the infomercial guy to train people One-On-One in one of his personal training facilities in Tehran and so and so… Move to Estonia! When I chose to move to Estonia at 2009 I also had to make a decision on a gym for me to workout in and also to present my best experiences and knowledge about coaching and sport supplements.first year only I collected all information about this field here in Estonia then I felt who is training seriously and professional then they need to use high quality supplements but there wasn’t in market that’s why I bring Universal and Ultimate Nutrition from united states to Estonia. I have been to a lot of bodybuilding and fitness centers already and based my decision in Estonia on my previous gym until now!I look at the gyms by different eyes and I see many things that 90% of owner’s gym don’t see it!there is sometimes so frail and sometimes so big thing that they should care and correct it if they would like to achievement on their job and if they don’t upgrade their knowledge all the times then always they will be 5 years retard than all other countries. Sometimes I see in gym there is young boys and girls,they have so good potential to grow so easy and they can be one of Estonian professional athlete and bring for country many shining medals and rise up the Estonian’s flag in international contest but unfortunately there is no body to recognition and find them to give opportunity and support! 5 Tips For Finding A Good Gym Here is a checklist you can use in searching for a fitness center: 1. Clean Facility: You want the facility to be cleaned regularly and have some type of cleaner on hand, near equipment, or in a storage area if need be. Some gyms I have been to have towels with the cleaning products - which are washed regularly - and other gyms have paper towels loosely placed throughout, or in dispensers around the facility. Remember though... no matter where you go you should always wash your hands regularly, and never touch your eyes, nose, or mouth without first washing your hands thoroughly with soap. 2. Equipment Variety: Any place you go should have a lot of fitness equipment variety for you to choose from. Many times while on vacation I have chosen the gym with the most equipment variety because I like to change my routines and exercises often. My body is never bored this way. If you sign up at a place with 10 pieces of equipment it is better than sitting on the couch, but you will soon go stale in your routines. This usually leads to boredom, which leads to dropping out. 3. Free Classes: If you go to a gym which offers classes - such as: aerobics, toning, sculpting, cycling, strength, cardio, abs and bun firming, or step - and they want you to pay separate then you should be alarmed. I have been to a lot of very nice high-dollar gyms in many different countries and do not ever remember seeing anyone have to pay extra. Now if you have a top expert or celebrity come to speak, hold a class, or workshop, that is totally different. Also you may have personal trainers or nutritionists hold classes in a gym for a fee because this is for their knowledge business. 4. Knowledgeable Staff: If you get to the front desk of a gym and there are only a few people on staff - barely over the age of 18 - and they are not well-trained (formally or informally) to help you get the fitness results you desire, then choose another gym. Some of us do not need a knowledgeable staff because we already have a game plan, but this is the minority of us. The majority of us will have questions and need a little guidance and assistance. You usually cannot get this from the young guy or girl behind the desk who works there just because they look like they are in shape or even some guys who trained some years. Getting yourself into shape and getting others into shape are two totally different ball games. If you see some bodybuilder it doesn’t mean this person is coach or reverse, coaching is only perfect knowledge. 5. Reliable: All too often, over the years, I have seen gyms rush into small and large towns and cities promising the world, only to really take your money and leave town. Many times you will see these gyms come into town with good marketing, but not good service once you are in the doors. You want a gym with a great track record of being open a long time. You want a gym with a history of being good to its members.You want a gym has real personal trainer who care about you if you do some exercise wrong. you want a gym that does not have a history of closing its doors after getting you signed-up for long-term contracts. If you have to sign-up for a long-term contract with a gym it usually means they want you to stay even if you do not want to. Conclusion many of the top gym chains around the country changed their model years ago to month-to-month memberships and I feel like that is what is right and fair to members. You want a gym that does not try to nickel and dime you and ask for service fees which are constantly hitting your pocketbook. You are at the gym to work on you, not on them! A gym can never please everyone, but if the majority of members are satisfied, then the gym is doing something right.

Thursday, April 19, 2012

Insulin!

Our body produces insulin; a protein secreted by the pancreas to regulate and maintains the levels of blood sugar in the body. Pancreas senses any increment in the blood sugar levels and secretes insulin to lower it. In the field of medicine it is used to treat diabetes. Surprisingly it also exhibits strong anabolic steroid making it a powerful steroid. How it Works Insulin gives impressive muscle mass gains similar to other anabolic steroids. Body builders and power lifters buy insulin to Gain weight as well. Basically insulin secreted by the body takes up glucose present in the blood and stores it in the muscle cells after converting it to glycogen. Glycogen in turn promotes protein synthesis and so the greater the quantity of glycogen in the cells the higher would be the protein absorption. Glycogen retention is the major driving force behind the muscle built up when insulin is used as a steroid. Another useful contribution of this drug which leads the steroid users to insulin is that it stops protein catabolism (break down of muscle protein); in this way more muscles are created which in turn leads to an increase in the muscle size. Insulin also strongly influences the IGF (Insulin like Growth Factor) in the body. The IGF promotes muscle growth. It is also instrumental in increasing the bone density in the body. Steroid users also buy insulin because it gives instant energy and so greatly increases the endurance level of the body. A body builder, power lifter or an athlete needs more endurance levels for intense training for the competition. High endurance levels mean that the user can train harder and for a longer period of time. Power lifters, body builders and athletes who want to gain weight quickly buy insulin as it can add considerable weight to the body in a short time. Most steroids use the fat stored in the body as fuel; insulin on the other hand prevents fat from being used as a fuel thereby giving considerable weight gains. Insulin was also found to increase the testosterone levels in the body. Though insulin can work wonders in body building, it can actually be fatal. Insulin when taken by non-diabetics can lead to a condition called hypoglycemia. In hypoglycemia, there is a marked decrease in the blood sugar level which may cause the user to faint. In extreme cases, hypoglycemia can lead to brain damage or cause death. Users are advised to eat anything rich in carbohydrates after injecting insulin. Drowsiness and hunger pangs after the injection are some symptoms of the onset of hypoglycemia. The user is advised to eat a rich sugary food if such symptoms occur. In short insulin as a steroid gives excellent results in muscle build up, weight gain and increased endurance levels. It is an inexpensive drug which is readily available and it is difficult to detect in a doping test; however it is quite “lethal” and can cause death. Types of Insulin There are various compositions of Insulin available in the market for athletic uses. Following are the five basic types of insulin commonly used by the athletes and body builders. • Insulin Humalog it is the fastest acting insulin • Insulin Humulin R it is effective for short duration • Insulin Humulin N it is an intermediate length composition • Insulin Humulin U it is also an intermediate length composition • Insulin –Humulin –U (utalente) it is a long acting composition Insulin Humalog is the best choice for athletes and body builders but unfortunately you cannot get it without a prescription. For this reason Humulin-Ris widely used by athletes and body builders as it can be obtained without a prescription. Humulin R peaks quickly and leaves the body rapidly too. The recommended dosage for insulin is 5 to 15 iu(international units) per day; however beginners are advised to start with a small dose of 1 to 2 iu per day.